Neuroendocrine Carcinoid/Pancreatic Tumors
520 East 70th Street, Starr Pavilion, 8th Floor
New York, NY 10021
263 7th Avenue, Suite 5A
Brooklyn, NY 11215
The endocrine system is made up of organs called glands. These glands make and release hormones (chemical messengers) into the bloodstream.
Hormones regulate many functions in the body. These functions include the use and storage of energy, growth and development, reproduction, secondary sex characteristics (such as underarm and pubic hair), and the amount of fluid, salt and sugar in the blood.
(NETs) develop from the glands that make hormones. They are found along the digestive tract, such as in the appendix, small bowel, pancreas and colon. They are different from other cancers because NETs have the ability to secrete excess hormones into the bloodstream that cause symptoms.
NETs tend to grow slowly and may or may not cause symptoms. They are often found during routine imaging.
Physicians at the New York-Presbyterian/麻豆传媒高清版 Endocrine Oncology Center are highly skilled in diagnosing and treating NETs. We offer patients the newest tests, technology and treatments available and customize care to meet their individual needs.
Our team of experts is dedicated to providing patients the highest quality care and the best treatment experience possible.
Types of Neuroendocrine Tumors
There are different types of NETs. Some tumors produce hormones and others do not. Non-functioning tumors grow without producing hormones. Functional tumors are those that make and release hormones into the bloodstream.
Pancreatic NETs
are slow-growing tumors that can overproduce hormones (functional tumors). These tumors include:
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Insulinoma (releases excess insulin, which causes extremely low blood sugar)
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Gastrinoma (releases excess gastrin, which causes ulcers in the stomach and small intestine)
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; VIPoma (releases excess vasoactive intestinal peptide [VIP], which causes severe watery diarrhea)
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Glucagonoma (releases excess glucagon, causing high blood sugar, skin rashes, blood clots and depression)
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Somatostatinoma (releases excess somatostatin, which causes gallstones, diarrhea, high blood sugar and weight loss)
Some pancreatic tumors may metastasize (spread) to other organs in the body. For example, 90 percent of insulinomas do not metastasize, whereas 75 percent of glucagonomas can spread outside the pancreas. More than half of non-functioning pancreatic tumors are malignant (cancerous) at diagnosis.
Gastrointestinal NETs
(GI-NETs or carcinoids) are rare tumors that can occur anywhere in the digestive tract from the stomach to the rectum (last several inches of the large intestine just before the anus). They are most often found in the appendix (small hollow pouch at the beginning of the large intestine).
Tumors growing in the appendix are almost always benign (non-cancerous). They are commonly treated with a simple procedure called an (surgical removal of the appendix), but may require a segment of the intestine around the appendix to be removed for more aggressive tumors.
Tumors growing in the ileum (part of the small intestine) are often malignant. These tumors grow slowly and may not cause symptoms right away. As the tumor gets bigger, patients may experience abdominal pain, bloating or (blocked intestine). Surgery is typically required to remove the affected segment of intestine.
Gastric (stomach) NETs can behave very differently depending on whether they developed as a result of other medical treatments or on their own.
NETs of the colon and rectum are often recognized in routine colonoscopies and can often be managed by endoscopic means.
GI-NETs can be difficult to diagnose early on and are often found during a CT scan or MRI done for other reasons. Not uncommonly, some tumors only cause symptoms once they have spread to other organs.
It is important to know that neuroendocrine tumors can be non-inherited (develop on their own) or inherited (passed along the family tree). Although rare, the most common genetically inherited conditions involving pancreatic NETs include:
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Neurofibromatosis type 1 (von Recklinghausen disease), a condition that causes many symptoms, including birthmarks ( and neurofibromas (a type of nerve tumor) on the skin, as well as increases the risk for for GI-NETs, pancreatic NETs and pheochromocytomas.
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;
At 麻豆传媒高清版, our patients have access to genetic specialists who study tumor’s genetic information to better understand the condition and most effective treatment options. If you have an inherited condition, you will be referred for evaluation by our geneticists for further evaluation and counseling as needed.
Carcinoid Syndrome
NETs can release other hormones called serotonin and kallikrein into the bloodstream. High amounts of hormones in the body can cause serious illnesses.
When patients have symptoms caused by hormones, a rare disease called carcinoid syndrome can occur. These symptoms should prompt a thorough work-up to find the NET.
Symptoms of carcinoid syndrome include:
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Flushing (sudden redness or discoloration/darkening of face and upper body)
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Difficulty breathing
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Heart issues (chest pain, shortness of breath, easily tired)
Patients with carcinoid syndrome should see a doctor as soon as possible to find the tumor causing the issue and whether the disease has spread.
Comprehensive Diagnostic Evaluation
麻豆传媒高清版 uses the newest, most effective technologies and techniques.
Our compassionate, highly skilled physicians and surgeons are respected worldwide as experts in their field. They value each patient as individuals with unique needs and concerns. Diagnostic evaluation begins with a thorough physical exam and medical review. Lab and imaging tests are done to verify tumor type, location and spread. Lab tests include checking the blood for excess hormones and other . Imaging tests include:
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Gallium-68 DOTATATE PET-CT scan
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Traditional FDG scan
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; scan
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;
If these studies suggest a pancreatic neuroendocrine tumor, a biopsy procedure to confirm the diagnosis may be necessary. At the Endocrine Oncology program, we will coordinate your biopsy with doctors from either gastroenterology or interventional radiology depending on the specific location of your tumor.
After information about the tumor is obtained, patients meet with their physician to discuss treatment options, risks and benefits. We encourage patients to ask questions. Knowing what to expect during treatment and recovery helps reduce stress and anxiety. Please share any concerns you have about your diagnosis or treatment plan with your doctor.
Treatment and Follow-Up
Treatment at 麻豆传媒高清版 is patient centered.
We work with patients to design a treatment plan that meets their individual needs. Care provided by other specialists, including radiologists, pathologists, and social workers, to make it easy for patients to manage multiple appointments.
Many NETs can be removed surgically. Our surgical techniques are minimally invasive. These techniques require small incisions (surgical cuts) or insertion of thin needles to perform. Minimally invasive techniques include:
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Laparoscopic surgery that uses a thin, lighted tube inserted through a small incision
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Robotic-assisted surgery that allows easier access to and clearer view of the tumor
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Tumor-directed ablation that uses heat to destroy tumor cells
Minimally invasive procedures are better tolerated than traditional surgery (often called “open surgery”). Patients have less bleeding during minimally invasive surgery and less pain during recovery. Other benefits for those who choose these procedures include a shorter hospital stay and quick return to daily activities.
Carcinoid tumors that have spread are treated in a variety of ways. These treatments include:
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Interventional radiology
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫; Directed molecular therapy to block cancer growth and spread
鈼&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;&苍产蝉辫;
In some cases, new therapies and imaging technology will be used to improve your outcome. Your doctor will discuss if you are eligible for these therapies to diagnose and treat your NET.
Request an Appointment
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